Binding of the proteoglycan decorin to collagen type VI.
نویسندگان
چکیده
منابع مشابه
Effects of decorin proteoglycan on fibrillogenesis, ultrastructure, and mechanics of type I collagen gels.
The proteoglycan decorin is known to affect both the fibrillogenesis and the resulting ultrastructure of in vitro polymerized collagen gels. However, little is known about its effects on mechanical properties. In this study, 3D collagen gels were polymerized into tensile test specimens in the presence of decorin proteoglycan, decorin core protein, or dermatan sulfate (DS). Collagen fibrillogene...
متن کاملDetermining the Mechanical Function of Type VI Collagen and Decorin in hMSCs undergoing Chondrogenesis
INTRODUCTION: The use of human mesenchymal stem cells (hMSCs) induced toward chondrogenesis has been considered for regenerative therapies in load bearing tissues, such as articular cartilage or the intervertebral disc (IVD). Chondrocytes are enveloped by a pericellular matrix (PCM) consisting of hyaluronic acid, type VI collagen (ColVI) and proteoglycans such as decorin (Dcn). In order to eluc...
متن کاملInteraction of the NG2 chondroitin sulfate proteoglycan with type VI collagen
The NG2 chondroitin sulfate proteoglycan is a membrane-associated molecule of approximately 500 kD with a core glycoprotein of 300 kD. Both the complete proteoglycan and a smaller quantity of the 300-kD core are immunoprecipitable with polyclonal and monoclonal antibodies against purified NG2. From some cell lines, the antibodies coprecipitate NG2 and type VI collagen, the latter appearing on S...
متن کاملRoles of type VI collagen and decorin in human mesenchymal stem cell biophysics during chondrogenic differentiation.
Human mesenchymal stem cells (hMSCs) induced towards chondrogenesis develop a pericellular matrix (PCM), rich in type VI collagen (ColVI) and proteoglycans such as decorin (DCN). Individual PCM protein functions still need to be elucidated to fully understand the mechanobiological role of this matrix. In this study we identified ColVI and DCN as important contributors in the mechanical function...
متن کاملCell adhesion to type-VI collagen.
In conclusion, we have provided experimental and theoretical evidence that the a-helical, coiledcoil domain of laminin is responsible for chain assembly and chain selectivity. None of the laminin chains appears to be designed for formation of homodimers, although these are common in many other fibrous proteins [ 111. Only selected heteroassociations are stable in laminin isoforms. The data on f...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1992
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)42759-7